An EC 1.6.3.* (oxidoreductase acting on NADH or NADPH with oxygen as acceptor) inhibitor that interferes with the action of NAD(P)H oxidase (H2O2-forming), EC 1.6.3.1.
ChEBI ID: 50423
| Member | Definition | Class |
|---|---|---|
| acetovanillone | An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3. | apocynin |
| diphenyleneiodium chloride | An organic chloride salt having dibenziodolium as the counterion. | dibenziodolium chloride |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (0.10) | 18.7374 |
| 1990's | 31 (3.04) | 18.2507 |
| 2000's | 313 (30.72) | 29.6817 |
| 2010's | 571 (56.04) | 24.3611 |
| 2020's | 103 (10.11) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 7 (0.67%) | 5.53% |
| Reviews | 14 (1.35%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,019 (97.98%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 11.2947 | 2 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 29.1056 | 3 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 32.1220 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 44.6684 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 0.0260 | 3 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 10.9633 | 3 | 3 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 6.3514 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 6.3096 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.2060 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 0.2133 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 1.1565 | 2 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 22.9833 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Dihydroorotate dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 10.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase (fumarate) | Saccharomyces cerevisiae S288C | IC50 | 10.0000 | 1 | 1 |